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Niska's skyplex was a space station orbiting Ezra owned by Adelai Niska. Malcolm Reynolds took his ship Serenity to visit this station in search for a job, which turned out to be the robbery of Pescaline D from a train on Regina. At the time he was there, at least two other ships were near the station, one was docked. The station is equipped with at least one fast-burn rocket shuttle for insertion and retrieval of its mercenaries to the planet below. The skyplex was staffed with an outfit of heavily-armed mercenaries, many of whom were killed or maimed when the crew of Serenity attacked the skyplex to rescue Captain Reynolds.
- In "The Train Job" when Serenity is first seen approaching the Skyplex, a Space Shuttle can be seen docked on the opposite side of the station.